imageBBB

 


Description
I want my work to inspire and lead pharmacy students into unexplored territories of research. For this reason, I chose to depict an innovative preclinical area of research that tackles a major health concern. Therapies for glioma are invasive and involve surgery to remove the bulk of the tumor because it is difficult to deliver anti-cancer drugs through the blood brain barrier (BBB). Nanomedicine can potentially provide a game-changer to patients afflicted with glioma because it provides a drug delivery method that bypasses the BBB.

The story begins with an overview of the nanoparticle. Dramatic perspective is utilized to lead the viewer’s eyes to the cut section of the nanoparticle. Dramatic perspective is utilized to lead the viewer’s eyes to the cut section of the capillary. The green nanoparticles are clearly visible against the complementary red of the capillary. Analogous colours are used to depict the various components of the BBB to create visual harmony. Through the placement of images, the viewer’s eyes flow to the enlarged cross section depicting the delivery of anticancer drug.

Intended Audience

Pharmacy students

Medium

Adobe Photoshop CS6,
Adobe Illustrator CS6

Intended format

Textbook print


Process Work

After conducting some research, I mocked up a few rough sketches to get some ideas flowing.
BBBOriginalSketches
Once my sketch was finalized, I proceeded to make two coloured sketches in Adobe Photoshop CS6.

BBBcolouredSketches

The final rendering process consisted of four stages:

    1. Final clean pencil outlines.
    2. Rough colour sketch in Adobe Photoshop CS6 was completed to determine final colour palate.
    3. Outline all elements in Adobe Illustrator CS6.
    4. Import outline Adobe Illustrator CS6 components into Adobe Photoshop CS6 for final rendering.

BBBProcess


References

Gabathuler, R. (2010). Approaches to transport therapeutic drugs across the blood- brain barrier to treat brain diseases. Neurobiology Disease 37, 48-57.

Ren, W.H, Chang, J., Yan, C.H., Qian, X.M., Long B.H., Yuan, X.B., Kang, C.S., Betbeder, D., Sheng, J., & Pue, P. Y. (2010). Development of transferrin functionalized poly(ethylene glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma. Journal of Materials Science Materials in Medicine, 21 (9): 2673-81.

Widera, A., Norouziyan, F., & Shen, W.C.,(2003). Mechanisms of TfR-mediated trasncytosis and sorting in epithelial cells and applications toward drug delivery Adavanced Drug Delivery Reviews. 55, 1439-1466